Dust in the Blood considers the harrowing realities of life with depression from a Christian theological perspective. In conversation with popular Christian theologies of depression that justify why this suffering exists and prescribe how people ought to relate to it, Jessica Coblentz offers another Christian approach to this condition: she reflects on depression as a wilderness experience. Weaving first-person narratives of depression, contemporary theologies of suffering, and ancient biblical tales of the wilderness, especially the story of Hagar, Coblentz argues for and contributes to an expansion of Christian ideas about what depression is, how God relates to it, and how Christians should understand and respond to depression in turn.